Misoprostol is a drug belonging to the group of synthetic prostaglandins of the PGE1 class. Has uterotonizing (stimulates contractions of the myometrium (the muscular membrane of the uterus), increases their strength and frequency), activates generic activity, gastroprotective (normalizes the secretion of gastric juice) and antiulcer effect.

After ingestion, misoprostol is actively absorbed into the bloodstream and reaches the site of its impact – the uterus. The drug stimulates the contractile ability of the myometrium, increases the frequency and force of contractions with the onset of labor, softens the cervix and increases the degree of its opening.

Indications for use

  • termination of pregnancy on terms of 16 to 23 weeks;
  • weakness of labor activity;
  • gastritis;
  • stomach ulcer;
  • peptic ulcer of the duodenum;
  • nonspecific ulcerative colitis;
  • Crohn’s disease;
  • erosion of the gastrointestinal tract caused by the use of non-steroidal anti-inflammatory drugs (Diclofenac, Nimisulide, Meloxicam).

Reception during lactation

During breastfeeding, the drug should not be consumed. In the case of mandatory Mizoprostol prescription, it is necessary to switch to the artificial feeding of a child with ready-made milk formulas. After the termination of the course of treatment, after 2-3 days the child can begin to apply to the breast.


There are several contraindications to taking Misoprostol:

  • hypersensitivity to the drug;
  • diabetes;
  • thyrotoxicosis;
  • epilepsy;
  • cardiac ischemia;
  • atherosclerosis of cerebral vessels and coronary arteries;
  • malignant neoplasms;
  • suspicion of ectopic pregnancy;
  • lactation;
  • children and adolescence up to 18 years.